胰高血糖素,代谢性疾病 z-bo 2020-10-29 298

　　Many health problems in developed countries stem from the destruction of the delicate metabolic balance between glucose production and energy utilization in the liver. A few days ago, in a research report published in the international journal Nature, researchers from Yale University found a A new molecular mechanism that may induce the metabolic imbalance between the two different but related processes mentioned above. Related research results may provide certain ideas and basis for the development of new therapies for the treatment of diabetes and non-alcoholic fatty liver (NAFLD) . The glucagon secreted by the pancreas plays a key role in the body's metabolism. Under food shortage, glucagon will initiate the production of glucose (necessary fuel for the brain) in the liver. This process is called glycogen Gluconeogenesis. In diabetic patients, the gluconeogenesis process is often disturbed. In this study, researchers revealed the molecular mechanism by which glucagon maintains the metabolic balance between glucose production and energy use in the liver.

　　Researcher Gerald Shulman said that by using a new method to assess liver metabolism, we can clarify the molecular mechanism of glucagon's effect. In previous studies, we focused on glucagon to reduce blood sugar in diabetic patients. However, related experimental therapies often have potentially serious side effects, including fatty liver caused by accumulation of liver enzymes.