代谢疾病 z-bo 2020-10-29 336

　　According to the results of a recent study, high testosterone levels increase the risk of metabolic diseases such as type 2 diabetes in women, while reducing the risk of related diseases in men. Higher testosterone levels also increase the risk of breast and endometrial cancer in women and prostate cancer in men. The relevant research was published in the journal Nature Medicine by the University of Cambridge and University of Exeter Medical Research Council (MRC) Leader of the epidemiological research group. Although studies have found that testosterone levels in men and women are strongly regulated by genetic factors, the authors found that genetic factors are very different between the sexes.

　　First, the team used a genome-wide association study (GWAS) among 425,097 UK Biobank participants, and identified 2,571 sex hormones "testosterone" and its binding protein "sex hormone binding globulin (SHGB)" Genetic variation associated with different levels. The researchers verified their genetic analysis in other studies (including the EPIC-Norfolk study and Twins UK), and found studies in the UK Biobank that were highly consistent with their results.