PGRMC2蛋白,代谢疾病 z-bo 2020-10-29 373

　　A signal protein called PGRMC2 (progesterone receptor membrane component 2) has not been extensively studied in the past. It is found in the uterus, liver and several other parts of the body. Now, in a new study, researchers from the Scripps Research Institute in the United States have found that this protein is abundant in fat tissues, especially in brown fat that converts food into heat to maintain body temperature. This opens the door to new insights about obesity and metabolism. Their findings may also bring new methods for the treatment of obesity and potentially many other diseases. The relevant research results have recently been published in the journal Nature.

　　This new study by Saez and his team is based on their recent discovery that PGRMC2 binds and releases an essential molecule called heme. This iron-containing molecule migrates within the cell, enabling vital life processes such as cell respiration, cell proliferation, cell death, and circadian rhythm. By using biochemical technology and advanced measurement methods in cells, Saez and his team discovered that PGRMC2 is the "chaper" of heme, wrapping this molecule and removing it from the cell's mitochondria (where heme is produced in the cell) Transported to the nucleus, where it helps to perform important functions. Without this protective partner, hemoglobin will react with all the molecules in its transport path and suffer damage.