2型糖尿病,抑制肥胖 z-bo 2020-10-29 414

　　Can we treat obesity or type 2 diabetes by changing the way cells clean up garbage? This is like a family that cannot function if it is filled with garbage. If a cell does not discard the garbage it produces, it will become unhealthy. However, the cell can decompose the garbage to produce energy. This process is called The process of autophagy.

　　Recently, in a research report published in the international journal Trends in Endocrinology and Metabolism, scientists from the University of Florida investigated the key role of autophagy in metabolic diseases such as obesity and type 2 diabetes. Researcher Professor Zhiyong Cheng said that autophagy is a special way of cell quality control. If an effective autophagy process cannot be carried out, the cell cannot renew itself. On the other hand, if there is too much autophagy, it will also It will destroy the balance of the cell's own components and induce cell death. Therefore, a moderately regulated autophagy process is essential to maintain the body's health.

　　Too much or too little autophagy is often directly related to the occurrence of various metabolic diseases in the body, such as obesity, type 2 diabetes and diabetic comorbidities. The researcher Cheng said, if we can find the culprit that triggers the abnormal autophagy process The culprit may be able to use it as a target to develop new therapies for a variety of diseases. This is a long-term research project in our laboratory. Previously, the researcher Cheng published a review describing the research results of the researchers on a variety of proteins that regulate autophagy. These proteins are called FoxO proteins. The researchers hope to use them as a key point to develop inhibition and obesity and type 2 diabetes. Related negative effects on body health.

　　The researchers said that in this study we identified FoxO1 protein, which is a member of the FoxO protein family. FoxO1 can act as a regulator of adipose tissue formation through autophagy. When the researchers block FoxO1, it will inhibit the whiteness. Fat production that stores energy, while also increasing the production of brown energy-burning fat. Since obesity comes from the expansion and over-formation of white fat, the targeting FoxO1 may be expected to inhibit obesity. In addition, the researchers described three main methods for investigating the relationship between FoxO-cell autophagy. One method is to observe the interaction between FoxO and DNA. This interaction is called transcription. FoxO binds to DNA so that the cell can initiate the autophagy process. The other method analyzes the DNA-dependent FoxO in the cell. The last one is the epigenetic method, which can investigate how environmental factors such as nutrients and stress affect the formation of FoxO. This method makes the researcher Cheng very excited.

　　The researcher Cheng said that we are most interested in explaining the relationship between FoxO and autophagy in terms of epigenetics, because this field is still in its infancy, so there are many unknowns in the future; in addition, through lifestyle Modification or intervention can effectively reverse the environment-induced FoxO epigenetic effects and the autophagy process of cells. The purpose of this study is to discover reliable epigenetic factors, which may promote early diagnosis of diseases and help develop new types Intervention measures to prevent the occurrence of various metabolic diseases.