糖尿病,肥胖,代谢疾病 z-bo 2020-10-29 291

　　A few days ago, in a research report published in the international journal Journal of Biological Chemistry, researchers from Louisiana State University clarified the effect of a protein in the treatment or prevention of metabolic diseases (such as obesity and diabetes). potential. Nischarin is the new type of protein discovered by the researchers. The researchers said that Nischarin can act as a molecular scaffold, maintaining and interacting with multiple other protein partners in a series of biological processes. In previous studies, the researchers found that Nischarin Proteins can act as tumor suppressors to inhibit the spread and metastasis of breast cancer and other cancers. In this study, the researchers found that Nischarin can interact with a gene named AMPK and control the activity of the gene by studying a gene knockout mouse model. AMPK can regulate the metabolic stability of the body, and Nischarin is eliminated. In the mouse body, the researchers found that the activity level of the gene that makes glucose decreased, and Nischarin can also interact with the gene that regulates glucose intake.

　　The researchers said that the gene knockout mice have lower glucose levels, but they have good tolerance to glucose and insulin. In addition, the researchers also found that Nischarin mutations can inhibit the expression of multiple genes, and these genes Mainly involved in lipid metabolism and fat accumulation in the liver; gene knockout mice also showed an increase in energy expenditure, although the decrease in their growth rate and the suppression of appetite caused a decrease in their food intake and Weight loss.