精氨酸酶II z-bo 2020-11-02 491

　　Arginase II originated in early life forms. It converts L-arginine into urea and ornithine to maintain various physiological functions of the body.

　　The increase in the level of arginase II in the body leads to the occurrence of cardiovascular diseases and certain chronic inflammatory diseases. There may be four reasons for the occurrence of these diseases: First, too much arginase II competes with nitric oxide synthase. -Arginine reduces the production of NO; second, the production of too much ornithine can lead to vascular structural changes and neurotoxicity; third, arginase II participates in certain inflammatory response signaling pathways, which ultimately leads to inflammation Fourth, arginase II can promote the inflammatory response of macrophages (with M1 phenotype).

　　This article reviews the role of arginase II in cardiovascular diseases and macrophages in recent years, as well as the mechanisms related to oxidative stress and inflammation, and provides a theoretical basis for clinically targeted arginase II to treat diseases.