脂肪肝,肝癌 z-bo 2020-11-02 328

　　In many countries including Japan, liver cancer caused by excessive accumulation of fat in the liver is increasing. In order to change this unfortunate situation, it is important to improve the prognosis of non-alcoholic fatty liver. In most cases, fatty liver is caused by overeating and lack of exercise. Fatty liver is usually improved by eating less, exercising more and losing weight. Therefore, the research team led by Fangping Jia of the Graduate School of Shinshu University posed a question: "Can eating less still inhibit liver cancer caused by fatty liver?"

　　An international research team led by Shinshu University School of Medicine was able to prove that reducing food intake by 30% or reducing the diet by 70% until fully fed can effectively reduce the possibility of developing liver cancer from fatty liver. Fatty liver is a very common disease that can lead to cirrhosis and cancer. The research team observed the incidence of fatty liver-related liver tumors in mice with hepatitis C virus core genes, and proved that the incidence of liver cancer dropped from 41% to 8% within 15 months only through dietary restriction.

　　Although there have been studies showing a link between obesity, fatty liver and hepatocellular carcinoma, the effect and mechanism of dietary restriction on cancer were not clear before this study. Reducing food intake can inhibit cell proliferation, oxidative/ER stress, inflammation, aging and insulin signaling, while increasing autophagy. Inflammation and oxidative/ER stress create an environment conducive to abnormal cell development in the body. Autophagy is the mechanism by which the body removes damaged cells and reduces the possibility of cancer.

　　Naoki Tanaka, associate professor of Shinshu University School of Medicine, is the corresponding author of the study. He hopes to eradicate cirrhosis and fatty liver cancer by providing personalized diet guidance and improving eating habits until the diet reaches 70%. Three other studies conducted by Associate Professor Tanaka using the same mouse model showed that a diet rich in cholesterol, saturated fat, and trans fat increases the incidence of liver tumors and clarified the mechanism of its occurrence. Associate Professor Tanaka speculates that not only fat intake is important, but also the "quality" of dietary fat that causes cancer. He hopes to further clarify this point in future research.

　　Many previous studies have also shown that dietary restrictions can delay the development of human cancer by slowing down the speed of aging. There is a Chinese proverb that says: "If you want to live a long and healthy life, eat until your stomach is 70% full." Then, you will live a healthy life, which may lead to a longer life.