细胞移植,脊髓损伤 z-bo 2020-11-03 364

　　The research group of Dr. Taki Tiraihi of Tarbiat Modares University School of Medicine in Iran found that motor neuron-like cell transplantation combined with glial cell-derived neurotrophic factor can reduce the formation of syringomyelia in injured rats and increase the density of nerve cells at the cell transplantation site; and The promotion of motor function recovery in rats with spinal cord injury is more obvious, and the effect is much better than other methods.

　　After transplantation, nerve cells derived from adipose stem cells can be integrated into the host spinal cord. However, the lack of an ideal microenvironment for the growth of nerve cells in the body has become a serious problem restricting their survival.

　　The research group of Dr. Taki Tiraihi of Tarbiat Modares University School of Medicine in Iran carried out the animal experiment of this project. 7 days after the spinal cord contusion of the rat, the motor neuron-like cells induced by adipose stem cells were injected into the center and head and tail of the spinal cord of the rat, and the glial cell-derived neurotrophic factor-gelatin sponge complex was implanted into the myelin sheath.

　　The results show that motor neuron-like cell transplantation combined with glial cell-derived neurotrophic factor can reduce the formation of syringomyelia in injured rats and increase the density of nerve cells at the site of cell transplantation; and it can promote the recovery of motor function in rats with spinal cord injury. Obviously, the effect is better than that of glial cell-derived neurotrophic factor, adipose stem cells, and motor neuron-like cells alone. It shows that this combination therapy is a potential method to repair spinal cord injury.