埃博拉 z-bo 2020-11-05 354

　　Working under strict biosafety conditions, researchers have discovered a series of laboratory mice that respond to the Ebola virus like humans—from lethal hemorrhagic fever to complete resistance— .

　　Their results show that genetic makeup plays an important role in determining the outcome of the disease, and their mouse disease model may be helpful for screening candidate therapies and vaccines.

　　Angela Rasmussen and colleagues tested the effects of Ebola virus on collaborative hybrid mice, which represented a hybrid of 5 classic laboratory mouse strains and 3 wild-type strains; they found that some small Mice are susceptible to the virus while others are resistant to the virus.

　　So far, no mouse model of Ebola infection has reproduced the hallmark symptoms of Ebola hemorrhagic fever, which include delayed blood clotting, internal bleeding and brown blood.

　　Rasmussen and her team also studied the genomes of these collaborative hybrid mice and proposed that an allele called Tek—which is known to activate clotting factors—may affect individuals’ susceptibility to the virus.