动物实验,高脂血症小鼠 z-bo 2020-11-06 313

　　Objective: To investigate the effect of the combined action of estrogen and male hormones on blood lipid levels and coagulation function in hyperlipidemia mice.

　　Method: After castration of mice, a hyperlipidemia model was established through a high-fat diet, and the mice were divided into 5 groups by giving different hormones. After the completion of the model building, blood was collected from mice, some of the mice were separated from serum to test the level of blood lipids, and some of the mice were separated from plasma to test the coagulation function.

　　Results: After a high-fat diet, the serum levels of total cholesterol, triglycerides and low-density lipoprotein in mice were significantly higher than those in the control group, and prothrombin time and activated partial prothrombin time were significantly shortened (P<0.05) , After giving estrogen androgen combination therapy, compared with the model, the serum total cholesterol, triglyceride and low-density lipoprotein levels of mice were significantly lower than those of the control group, prothrombin time and activated partial prothrombin time Significantly prolonged (P<0.05), but no significant difference from the control group.

　　Conclusion: Combination therapy with estrogen and androgen can regulate blood lipids, significantly reduce the level of low-density lipoprotein, and regulate blood coagulation, suggesting that the combined action of estrogen and androgen can reduce the risk of coronary heart disease and provide new ideas for hormone therapy of coronary heart disease.