子宫内膜异位症 z-bo 2020-11-06 341

　　Objective: To establish a mouse model of endometriosis and observe the effect of endometriosis on the pregnancy ability of the model mice.

　　Methods: A mouse model of endometriosis was established by the "abdominal cavity + subcutaneous" allogeneic endometrial injection method, compared with the sham operation group and the blank group, the pregnancy rate and the live birth rate were observed, and the endometriosis was observed The effect of syndrome on the pregnancy ability of model mice.

　　Results: After 2 weeks of modeling, there were endometriotic lesions in the subcutaneous and abdominal cavity of the mice. There were three groups: model group, sham operation group and blank group. Through the test of fertility function, the difference in pregnancy rate of the three groups was significant (P<0.05). The difference in the number of live births in the three groups was significant (P<0.05).

　　Conclusion: Successfully established a mouse model of endometriosis, and confirmed that endometriosis can affect the reproductive function of model mice.