IGF-1基因 z-bo 2020-11-10 282

　　Objective: To study the effect of IGF-1 gene therapy on the rat model of postpartum stress urinary incontinence and explore the ideal treatment method for the disease.

　　Methods: 240 SD female rats were modeled by the vaginal dilatation method, 148 were randomly selected from 185 successful models and divided into 5 groups, and they were treated with IGF-1 gene therapy, amino antagonist drug therapy, electrical stimulation therapy, Empty plasmid vector injection and untreated, another 20 unmodeled rats were selected as blank control, and each group was tested for urodynamics and serum biochemical indicators (LDH, CK) at 1, 21, 42 and 63 days after treatment. And so on, and observe the changes of the pubococcygeus muscle fibers under a light microscope.

　　Results: At 21 days after treatment, the IGF-1 group and the electrical stimulation group had better therapeutic effects regardless of the maximum bladder volume, the pressure at the leak point or the contraction force/muscle weight ratio; while the IGF-1 group and the electrical stimulation group had two There was no significant difference between the groups (P>0.05).

　　Conclusion: IGF-1 gene therapy and electrical stimulation therapy are better than other groups such as drug therapy on the rat model of postpartum stress urinary incontinence.