微生物源性抗氧化剂 z-bo 2020-11-12 297

　　Objective: To explore the effects of different doses of microbial-derived antioxidants on sleep and antioxidant properties in mice.

　　Methods: 60 male Kunming mice were randomly divided into 4 groups. The low, medium and high dose groups were fed with 0.5 g/kg body weight, 1.0 g/kg body weight and 1.5 g/kg body weight microbial antioxidants, respectively. The control group was used Gavage with normal saline for 30 days. After the last gavage, the animals in each group were injected with sodium pentobarbital into the abdominal cavity, and the sleep status of the mice was observed through the righting reflex test. After the end, the anti-oxidation performance of the mice's serum was tested.

　　Result: Compared with the low and high dose groups, the microbial-derived antioxidants in the middle dose group can significantly prolong the sleep time of pentobarbital sodium (P<0.05). Compared with the control group, low-dose and high-dose groups, the middle-dose group significantly increased the activity of GSH-Px (P<0.01) and significantly increased the activity of SOD (P<0.05). Compared with the control group, the contents of MDA and 8-ISO-PGF2α in the middle-dose group were significantly reduced (P<0.05).

　　Conclusion: It is suggested that microbial-derived antioxidants can promote sleep in mice and improve the body's antioxidant capacity, and the effect is the most significant at a dose of 1.0g/kg body weight.