大鼠胫骨骨缺损修复 z-bo 2020-11-12 376

　　Objective: To observe the effects of calcium phosphate cement (CPC) and lithium chloride composite calcium phosphate cement (Li/CPC) on fracture healing in SD rats.

　　Methods: Twenty 6-month-old female SD rats were set up to establish Li/CPC experimental group (n=10) and CPC control group (n=10), and underwent bilateral tibial bone defect filling surgery, 1 and 2 months after operation Five rats in each group were sacrificed, and tibia specimens were taken for micro-CT (Micro-CT) detection and histological section HE staining for comparative analysis.

　　Results: Micro-CT scan showed that the effect of bone defect repair in the Li/CPC group was better than that in the CPC group, the volume fraction of new bone around the material (BV/TV) in the Li/CPC group was higher than that in the CPC group, and the trabecular bone separation (Tb.Sp) ) Is small, and the difference is statistically significant (P<0.05); histological HE staining showed that fibrous callus and osteoid callus in Li/CPC group appeared earlier and in larger numbers, and the quality of bone healing was significantly higher than that in CPC group .

　　Conclusion: Li/CPC has good bone conduction performance and can obviously promote bone defect repair.