小鼠实验,脑梗后遗症 z-bo 2020-11-13 454

　　The research team of Nara Prefectural Medical University in Japan announced recently that they have successfully discovered a genetic gene necessary for the human body to distinguish smell. This result is of great significance for the exploration of the odor perception mechanism and the development of treatments for the sequelae of cerebral infarction.

　　The team led by Professor Akio Tsuboi of the school completed relevant experiments. The specific results have been published in the well-known American scientific journal "Journal of Neuroscience".

　　The research team focused on the granular cells in the olfactory bulb, which is an important part of the forebrain structure that participates in olfactory activities. The researchers conducted a detailed investigation of the 5T4 gene in the granular cells of the olfactory bulb through mouse experiments.

　　Using gene editing technology to cause 5T4 gene damage mice, their sensitivity to smell is only 1% of the sensitivity of normal mice, and also lose the ability to distinguish between two flavors. Normal granule cells have 5-6 branch-like processes, which are connected to other nerve cells, while the granule cells of mice with 5T4 gene damage have only 2-3 branch-like processes.

　　Professor Tsuboi said: “The granule cells will generate information processing circuits that can distinguish the intensity and type of odor due to the activation of the 5T4 gene. If the 5T4 gene can be manipulated through drugs and other methods, it is very likely to be damaged by diseases such as cerebral infarction. The regeneration of brain circuits is of great significance to the development of new therapies that can inhibit sequelae such as numbness of the limbs."