小鼠实验 z-bo 2020-11-13 307

　　Recently, in a research report published in the international journal The FASEB Journal, researchers from the University of Tennessee Health Science Center found that the estrogen receptor β-mediated chemical called Beta-LGND2 Sexual activation may be able to convert harmful fat (white fat) into beneficial fat (brown fat), thereby reducing the risk of obesity and metabolic diseases. Researchers say that brown fat can significantly increase metabolism and promote weight loss.

　　Researcher Ramesh Narayanan said that although there is a common misunderstanding that obesity is not a life-threatening disease, obesity is the cause of many fatal diseases. There is an urgent clinical need for safe and effective treatments for obesity. Targeting ER-β seems to be a new strategy to safely fight against obesity.

　　In order to conduct this study, the researcher Narayanan and colleagues used three groups of mice to conduct the study. The first group of mice were fed a normal rodent diet, and the other two groups were fed a high-fat diet to make them quickly obese. One group of high-fat diet mice was treated with transportation vehicles, while the other group of mice was treated with Beta-LGND2. The researchers found that compared with other high-fat diet mice, the use of Beta-LGND2 was less effective. The mice were obviously thinner, and the mice treated with Beta-LGND2 had higher body temperature and larger oxygen consumption, which indicated that these mice had higher metabolic rate.

　　Finally, the editor-in-chief Thoru Pederson said that in many parts of the world, the pre-diabetes symptoms of metabolic syndrome and obesity itself will continue to threaten the health of millions of people. Now we need more researchers to participate in similar related research, and Given the latest research data, we have known for a long time that fat in the body can exist in two physiological forms, but in this article we are more concerned about how to turn on the beneficial pharmacological switch of fat to promote the conversion of harmful fat into Good fats, thereby helping to reduce obesity.