聚氧化乙烯 z-bo 2020-11-16 328

　　Objective: To evaluate the effect of polyethylene oxide (PEO) on the blood perfusion of chronic ischemic hindlimbs in rats by contrast-enhanced acoustic imaging.

　　Methods: Twelve Wistar rats established a chronic hindlimb ischemia model by ligating one femoral artery. Then, the rats were randomly divided into experimental group and control group (n=6), and PEO and physiology were infused via internal jugular vein the next day Saline, a total of 2 weeks of treatment. At different time points, the blood flow of the skeletal muscle of the ischemic hindlimb of the rat was measured by contrast-enhanced examination and the blood flow reserve was measured on the 28th day.

　　Results: From the 7th day, the blood flow of the ischemic hindlimb skeletal muscle of the PEO group was higher than that of the control group (P<0.05). On the 28th day, the blood flow reserve and vascular volume of the ischemic hindlimb skeletal muscle of the PEO group were significantly higher Control group (P<0.05).

　　Conclusion: PEO significantly increases the blood flow reserve and blood flow of the skeletal muscle of chronic hindlimb ischemia model rats, and increases the vascular volume of the skeletal muscle of chronic hindlimb ischemia, suggesting that PEO may promote angiogenesis and arteries by increasing the shear force of blood flow Formation process, thereby improving blood perfusion of ischemic hind limbs.