高龄大鼠运动机能 z-bo 2020-11-16 377

　　Objective: To investigate the changes of rat's motor function with increasing age and the effect of exercise on improving the motor function of elderly rats.

　　Method: SD rats of 26 months, 8 months and 2 months of age were treated with moderate-intensity treadmill exercises for 2 weeks. Four functional indicators of forelimb tension, endurance, physical upward mobility and ultimate speed were measured before and after exercise. , Conduct comparative analysis.

　　Results: ①The 26-month-old rat group's forelimb tension, endurance, physical upward mobility, and ultimate speed were significantly lower than those of the 8-month-old group and the 2-month-old group, and the latter three indicators showed a decline with age; ②26-month-old and The forelimb pulling force of the 8-month-old group was higher after exercise than before exercise, and the upward mobility of the 8-month-old group and the 2-month-old group was higher after exercise than before exercise; ③To compare the total motor function scores of 4 indicators before and after exercise intervention, The 26-month-old group after exercise was significantly higher than before exercise.

　　Conclusion: The four motor function indexes of rat's forelimb tension, endurance, body upward movement ability and limit speed show aging decline, which can be used as an aging indicator of rat's motor function. Moderate-intensity treadmill exercise can significantly improve the decline of the total exercise function of elderly rats.