动物实验,钙螯合胶原多肽 z-bo 2020-11-17 763

　　Purpose: To compare the bone quality improvement effect of Calcium Chelated Collagen Polypeptide (CPCC) with estrogen, to lay the foundation for the development of safe osteoporosis (OP) prevention and treatment drugs.

　　Methods: Excise both ovaries in rats, set up ovariectomy group (OVX), sham operation group (sham), 17β-estradiol (OVX+E2) injection group and CPCC gavage group (OVX+CPCC), 9 weeks later Compare the bone index and blood biochemical index of each group.

　　Result: The femoral bone density in the OVX group was significantly lower than that in the sham group (P<0.01), indicating="" that="" op="" occurred.="" like="" cpcc="" can="" effectively="" inhibit="" the="" abnormal="" changes="" of="" measured="" indicators="" and="" maintain="" them="" at="" level="" sham="" group="" p="">0.05). However, in terms of inhibiting weight gain, the body weight of the E2 group was significantly lower than that of the sham group at the 8th and 9th weeks (P<0.01); in terms of preventing the loss of bone mineral and bone organic matter, the Mg and Ca levels of the E2 group were significantly lower than those of the CPCC. In the high-dose group, the level of Cu was not different from that of the sham group, while the CPCC (medium and low-dose) was significantly higher than that of the sham group. The levels of Mn, Zn, and hydroxyproline in the E2 group were significantly lower than those in the sham group, while CPCC could be maintained at the level of the sham group. The inhibitory effect on the increase of BGP and StrACP levels in the blood was not significantly different between the E2 group and the OVX group, and the CPCC group was significantly lower than that of the OVX group. When inhibiting the decrease of blood calcium level, there was no significant difference between the E2 group and the OVX group, while the CPCC group was significantly higher than the OVX group.

　　Conclusion: Calcium chelated collagen peptide is more effective than estrogen in improving the bone quality of ovariectomized rats.