动物实验,流感病毒 z-bo 2021-10-14 373

　　Influenza virus is prone to a worldwide pandemic due to its rapid mutation, rapid spread, general susceptibility of the population, and difficulty in control. The human influenza pandemics that have occurred in the 20th century include the H1N1 Spanish influenza in 1918, the H2N2 Asian influenza in 1957, the H3N2 Hong Kong influenza in 1968, and the new type A H1N1 influenza that swept the world in 2009. The influenza pandemic has seriously threatened human health and caused Major economic losses and social panic. In addition, since the outbreak of human infection with H5N1 highly pathogenic avian influenza in Hong Kong in 1997, the cross-species transmission of avian influenza virus (AIV) has also attracted great attention, and the number of human infections of avian influenza and the region have been increasing. . The H7N9 epidemic broke out in my country in 2013; in May of the same year, Taiwan reported the first case of human infection with H6N1 avian influenza virus; at the end of 2013, another case of H10N8 infection occurred in my country; the first case of H5N6 infection occurred in Sichuan and Hunan in 2014.

　　In order to respond to a possible influenza pandemic, study the pathogenic mechanism of influenza viruses, and develop new influenza vaccines, many laboratories around the world are carrying out influenza research, and influenza virus animal infection experiments are an indispensable part of these studies. As influenza virus animal infection experiments have certain risks and threaten the health of researchers and even the public, various countries have strict regulations on the level of biosafety laboratories required to engage in animal infections of different types and subtypes of influenza viruses. This article combs the relevant domestic and foreign laws and regulations and documents, discusses the biosafety classification and biosafety management of influenza virus animal infection experiments, for reference by colleagues who carry out influenza virus infectious animal experiments.