动物实验,疗自闭症社交缺陷 z-bo 2020-11-18 384

　　American scientists found through animal experiments that the anti-cancer drug romidepsin can restore normal operation of a group of genes related to brain function and alleviate the social behavior defects of autistic experimental mice.

　　Researchers at the State University of New York at Buffalo said that the new study used low-dose romidepsin for a 3-day treatment in experimental mice with autism due to a Shank 3 gene defect and found that the effect of improving social behavior can be improved. Lasts for about 3 weeks, which is equivalent to a few years for humans.

　　The research team has previously discovered that Shank 3 gene is an important autism risk gene, and its defect can make histone deacetylase 2 levels too high, erroneously inhibiting a number of genes related to brain nerve signal transmission. These genes have not been mutated, but they cannot function normally due to the failure of upstream regulation, leading to autistic behavior.

　　Romidepsin itself is a histone deacetylase inhibitor used to treat certain T-cell lymphomas. It can prevent histone deacetylase from exerting its effect, relieve the restriction of the above-mentioned genes, and restore normal expression.