动物实验,脂肪肝 z-bo 2020-11-18 372

　　An experiment with mice found that exposure to electronic cigarettes increases the risk of fatty liver in mice. Researchers say this reminds people to use e-cigarettes more carefully.

　　The electronic cigarette is mainly composed of a battery, an evaporation device and a cigarette tube containing a smoke liquid. The smoke liquid contains a certain amount of nicotine. Many people use electronic cigarettes as a smoking cessation aid.

　　Researchers from Charles R. Drew University of Medical Sciences in the United States reported on the 18th at the annual meeting of the American Endocrine Society in Chicago that e-cigarettes have become more and more popular in recent years, and some advertisements claim that e-cigarettes are safer than traditional cigarettes. But their experiments on mice showed that exposure to electronic cigarettes can cause extra accumulation of liver fat, which is harmful to health.

　　Research leader Theodore Friedman said: “We have concluded that e-cigarettes are not as safe as advertised.” He believes that the results of this research have important implications for public health and tobacco regulatory policies.

　　Previous studies have confirmed that the nicotine in traditional tobacco is related to non-alcoholic fatty liver, but there is a lack of research on the long-term effects of electronic cigarettes on the liver.

　　In the 12-week experiment, all mice were fed high-fat, high-cholesterol food. One group of mice was exposed to the aerosol environment formed by e-cigarettes until their blood nicotine levels were comparable to those of smokers or e-cigarettes. The mice in the control group were placed in a nebulized saline environment.

　　Researchers collected liver samples from these mice and used RNA (ribonucleic acid) sequencing technology to analyze their genes affected by e-cigarettes.

　　It was found that the liver samples of mice exposed to electronic cigarettes had abnormalities in 433 genes related to fatty liver. In addition, genes related to the biological clock in this group of mice have also changed, and biological clock disorders can accelerate the course of liver diseases including fatty liver.