维生素D缺乏,糖尿病大鼠 z-bo 2020-11-18 366

　　Objective: To investigate the effect of vitamin D (VD) deficiency on the pathogenesis of spontaneous diabetic rats.

　　Methods: Male Zucker control mice and model mice (ZDF) aged 5 to 6 weeks were randomly divided into 4 groups according to their body weight, namely normal control group (ZL)? VD lack control group (ZL + VD. Def)? Model group (ZDF) And VD lack model group (ZDF + VD. Def). The rats in each group were fed to 12 weeks of age. During the feeding process, the body weight, food intake, water consumption, urine volume, urine sugar, and blood sugar were monitored, and oral glucose tolerance test was performed at 11 weeks of age; HE staining was used to observe the morphological structure of rat islets Change.

　　Results: The weight of rats in the VD-deficient model group was significantly higher than that of the model group; the increase in water intake and urine volume appeared earlier than the model group; the blood glucose of the rats in the VD-deficient model group increased significantly earlier than the model group, and the VD-deficient model at various stages The blood glucose of the group was significantly higher than that of the model group, about 2.0 times that of the model group at 12 weeks of age; compared with the model group, the glucose tolerance of the VD-deficient model group was impaired. The islet cell damage is more serious.

　　Conclusion: VD deficiency accelerates and aggravates the onset of diabetes in ZDF rats. VD deficiency is a key factor in the onset of obese T 2DM.