糖尿病大鼠 z-bo 2020-11-21 357

　　Objective: To observe the effects of maca combined with exercise therapy on the activity of renal mitochondrial respiratory enzymes and renal function in diabetic rats.

　　Method: 40 diabetic model rats were randomly divided into model control group, maca group, exercise group and maca+exercise group. Maca group and maca+exercise group were given daily maca powder (5g/kg) , Exercise group and maca + exercise group for treadmill training. After 6 weeks, rats in each group performed exhaustive exercise (35m/min), and then immediately anesthetized the kidney mitochondria, and measured the mitochondrial respiratory chain enzyme RCCI, RCCII, RCCIII, RCCIV Activity and blood urea nitrogen (BUN), serum creatinine (SCr), blood glucose (bloodglucose) content.

　　Results: Compared with the control group, the renal mitochondrial respiratory chain enzyme RCCII in the maca group, exercise group RCCI, RCCII, and maca+exercise group RCCI, RCCII and RCCIV activities were significantly increased; compared with the maca group, maca+exercise The activity of RCCI and RCCII in the group increased significantly; compared with the exercise group, the activity of RCCII in the maca + exercise group was significantly increased. Compared with the control group, the blood urea nitrogen content of the maca group, the maca + exercise group, the exercise group, the Serum creatinine and blood glucose levels in the coffee + exercise group decreased, and the difference was significant (P<0.05 or P<0.01); compared with the maca group, the serum creatinine and blood glucose levels in the maca + exercise group decreased, and the difference was significant (P< 0.05); Compared with the exercise group, the Maca + exercise group blood urea nitrogen and blood sugar levels decreased, the difference was significant (P<0.05).

　　Conclusion: Maca combined with exercise therapy can improve renal mitochondrial respiratory function in aged diabetic rats, increase the level of oxidative phosphorylation, and improve renal function.