大鼠骨生长 z-bo 2020-11-23 338

　　Objective: To observe the effect of different doses of fluoride and aluminum combined intake time on the longitudinal bone growth and bone metabolism in rats.

　　Methods: 48 8-week-old clean SD rats weighing 170~190g were randomly divided into normal control, low-fluoride aluminum and high-fluoride aluminum groups, and set up 45d and 90d groups respectively. Proximal tibial growth plate and metaphyseal pine Bone morphometric analysis of qualitative bone.

　　Results: Compared with the normal group, the growth plate of the high fluoride aluminum group was thickened, the chondrocytes in the 45d group were clear, neatly arranged, and no abnormal shape, while the 90d group chondrocytes were crowded and retained; the low fluoride aluminum (45d and 90d) group had metaphyses End-secondary trabecular bone mineralization perimeter, bone formation rate, and osteoblast perimeter all increased, and the bone resorption perimeter increased in the 90d group; the above bone metabolism indexes increased in the high fluoride aluminum 45d group, and decreased in the 90d group ｡

　　Conclusion: Short-term exposure to high-fluoride aluminum stimulates cartilage growth and long-term inhibition of longitudinal bone growth. Short-term exposure to low-fluoride aluminum only increases secondary trabecular bone formation. Long-term exposure to low-fluoride aluminum and short-term exposure to high-fluoride aluminum can stimulate trabecular bone formation and increase Bone resorption, high fluoride aluminum inhibits bone formation and resorption for a long time.