兔颅骨缺损 z-bo 2020-11-23 449

　　Objective: To observe the effects of micro-arc oxidation and alkali treatment on the surface properties, biocompatibility and osteogenic ability of porous tantalum.

　　Method: After micro-arc oxidation and alkali treatment of porous tantalum sheet, scanning electron microscope observes the number of surface micropores, surface calcium and phosphorus deposition and contact angle. Tantalum sheet is implanted to repair rabbit skull defect model, and bone healing is observed at 4 and 12 weeks.

　　Results: Scanning electron microscopy showed that there were more micropores, calcium and phosphorus deposits on the surface of the treatment group, and a smaller contact angle (P<0.05). After the porous tantalum sheet was implanted, all animals grew well and the wounds healed well. CT observation was porous The tantalum sheet and the surrounding bone tissue are well coupled; the calcein labeling test shows that new bone grows into the hollow tantalum material at 12 weeks; scanning electron microscope observation shows that there are new blood vessels in the hollow tantalum material at 4 weeks, and there are small bones at 12 weeks The beam grows into the material.

　　Conclusion: Micro-arc oxidation and alkali treatment can change the surface shape of porous tantalum materials. After treatment, the porous tantalum sheet has good biocompatibility and osteogenic ability.