肥胖 z-bo 2020-11-25 377

　　Objective: To evaluate the effect of high-fat diet-induced obesity on the ovarian function of female rats and explore its mechanism of action.

　　Methods: 80 female Wistar rats were randomly divided into a high-fat diet (HFD) group (n=40) and a normal diet (control) group (n=40). After 60 days of feeding, the estrus cycle and follicles of each group were evaluated The number of cells and apoptosis in each stage of development, and the concentration of serum progesterone and estradiol in each group of rats were detected. Then the male and female rats were caged at a ratio of 1:2 for 3 weeks.

　　Results: HDF induced obesity and hyperglycemia in rats, but did not affect the serum triglycerides, cholesterol and C-reactive protein concentrations. Obesity also changed ovarian function, prolonged estrus interval in HFD rats, and decreased serum estradiol concentration And the number of antral atresia follicles increased. In addition, the rats in the HFD group also developed follicular cysts. Moreover, the rats in the HFD group became pregnant later than the rats in the control group.

　　Conclusion: Obesity induces follicular cysts in rats and interferes with ovulation, leading to delayed pregnancy.