高脂血症小鼠 z-bo 2020-11-25 375

　　Objective 　 To explore the regulation of ferulic acid (ferulicacid) on hepatic steatosis and intestinal flora in hyperlipidemia mice.

　　Methods Twenty-four 6-week-old male ApoE-/- mice were randomly divided into 4 groups (n=6), namely control group, model group, ferulic acid group [40mg/(kg.d)], simvastatin group [5mg/(kg.d)], another 6 C57BL/6 mice of the same age were taken as the blank group. After 12 weeks of high-fat feeding, the mice were treated with administration for another 12 weeks. The feces of mice were collected for intestinal flora detection, blood lipid levels were detected, and liver sections were made to observe pathological changes.

　　Results Compared with the control group, the body weight, serum total cholesterol (total cholesterol, TC), triglyceride (TG), low-density lipoprotein (low-density lipoprotein (PC)) of the model group increased significantly. 0.05), the liver section showed that the mouse liver cytoplasm was filled with lipid droplets, and most of the liver cells showed fatty degeneration. The number of bacteria in the model group Firmicutes and Erysipelotrichaceae increased. Bacteroides Compared with the model group, the weight, serum TC, TG, LDL-C of the mice in the ferulic acid group significantly reduced liver steatosis, and the phylum and Firmicutes were significantly reduced. The number of bacteria of the Veronococcus family decreased, and the number of Bacteroides, Rumen bacteria and Odoribacter increased.

　　Conclusion 　 Ferulic acid can improve dyslipidemia and liver steatosis in mice, and regulate the imbalance of intestinal flora.