z-bo 2020-12-01 389

　　Objective: To use dual-source CT scanning and X-ray fluoroscopy to establish a tracing model of the distribution of sodium hyaluronate (HA) in the rabbit knee joint cavity, and to observe the effect of the difference in the administration site on the distribution of HA in the rabbit knee joint cavity . Method: Using iohexol as a tracer, prepare 0.5 ml sodium hyaluronate-iohexol (HA-I) mixed preparations with iohexol concentrations of 2.5%, 5%, 10%, 20%, and 40%. After injection into the rabbit’s knee joint cavity, dual-source CT is used to perform plain scan and three-dimensional reconstruction to screen the best tracer concentration that can effectively distinguish the drug from the surrounding tissue. Subsequently, 0.5 ml of HA-I preparation with the best iohexol concentration was injected into the joint cavity of the rabbit's knee from the two administration sites under the patella and the joint line. Dual-source CT and X-ray fluoroscopy were used to observe the drug in the knee joint cavity. The difference in distribution characteristics confirms the effectiveness of the drug tracing model. Results: The CT value of HA-I mixed preparations increased with the increase of the concentration of iohexol. When the concentrations of iohexol were 2.5%, 5%, 10%, 20%, and 40%, the soft tissues of the knee joint and HA-I preparations The ratios of the average CT values of and bone tissue were 2:7:46, 2:14:44, 2:28:44, 2:60:46, 2:98:45, which confirmed that 5%~10% iodine The alcohol concentration HA-I mixed preparation can most effectively distinguish the drug from the surrounding tissues, and obtain the most ideal three-dimensional reconstruction effect of the drug distribution range. A HA-I preparation with a concentration of 5% iohexol was taken for CT scan and X-ray tracing observation. The results showed that the difference in the administration site was related to the distribution of the drug. The HA administered under the patella was mainly distributed in the patellofemoral joint , HA administered by the joint line is mainly distributed in the tibiofemoral joint. Conclusion: The HA-I preparation with 5% iohexol concentration combined with CT scan and X-ray fluoroscopy can effectively distinguish the drug from the surrounding tissues and visually display the distribution range of the drug in the joint cavity. It is a reliable HA drug tracing model .