动物造模 z-bo 2022-02-03 463

　　[Modeling mechanism]: Atrial fibrillation often occurs after thoracotomy, and pericarditis is an important cause of atrial fibrillation.

　　[Modeling method]: After anesthetizing the male or female dogs of mixed dogs, open the chest and cut the bag to expose the heart. Three sets of stainless steel wire electrodes are used to suture the predetermined right atrium and spray on the surface of the atrium. Wrap a large amount of sterile talcum powder in a gauze cloth, suture the pericardium and chest wall to prevent penicillin infection. During postoperative healing, atrial fibrillation is triggered by pre-stimulation or rapid increase in atrial fibrillation stimulation for 10-30 seconds.

　　[Model Features]: Atrial fibrillation easily occurs within 4 days after surgery. After 7 days, the induction rate of atrial fibrillation dropped to 1/5,

　　[Evaluation and application of the model]: This model is simple, fast, and has a high induction rate. It is often used in the research of therapeutic drugs.