关节炎小鼠模型,金黄色葡萄球菌 z-bo 2020-12-03 332

　　Objective: To establish and analyze the arthritis model of conditional Staphylococcus aureus infection, and provide an animal model for studying the mechanism of arthritis and drug development.

　　Method: First treat mice with cyclophosphamide immunosuppressive agents, and then inject Staphylococcus aureus into the tail vein and the model by observing joint appearance characteristics, arthritis index analysis and pathological observation scores. Results: From the first day of vaccination, the joints of the mice were slightly swollen, and the lesions in the joint tissues ranged from a small amount of synovial hyperplasia and position disorder to thickening of the synovial membrane, spread to the joint cavity, and facilitated it to develop into a spherical penetration .

　　Conclusion: The successful establishment of a SA model of conditional infection can simulate the clinical symptoms and course of human arthritis in a relatively short period of time, reflecting the etiology of human arthritis from the aspects of infection and immune mechanisms.