动物造模 z-bo 2022-02-03 410

　　[Modeling mechanism] Acute ischemia delays the conduction of impulse in the atrial ischemic area and makes reentry easy to form, leading to the occurrence of atrial fibrillation.

　　【Method of Modeling】: Choose adult mongrel dogs, male or female. Tracheal intubation was performed after anesthesia. After disinfection, the chest was opened along the midline, and electrodes were placed in the left and right auricles to mark the heart's electrical activity and stimulate the atria. Double ligation of the right middle atrium artery (perfuse the free wall of the right atrium) for 0.5 to 3 hours. S1S2/S1S1 trigger stimulus to induce atrial fibrillation.

　　[Model Features] Histological examination revealed obvious necrosis in the atrial ischemic area, and electrophysiological mapping showed that the conduction velocity in the ischemic area was significantly slowed down. Compared with non-ischemic atrial muscles, atrial fibrillation in ischemic areas is easier to induce and lasts longer.

　　【Model Evaluation and Application】This model can be used to study the mechanism and treatment of coronary heart disease and atrial fibrillation.