高血压合并高脂血症大鼠模型 z-bo 2020-12-07 326

　　Objective: To feed spontaneously hypertensive rats (SHR) with high-fat diet to construct a rat model of hypertension combined with hyperlipidemia, and evaluate its heart and kidney damage. It is a therapeutic drug for hypertension combined with hyperlipidemia Evaluation provides reference for pharmacodynamic animal models and related methods.

　　 Method: 3 weeks old SHR were randomly divided into a blank control group and a model group; at the same time, Wistar-Kyoto (WKY) rats with normal blood pressure at the same age were selected as the model control group. The blank control group and the model control group were fed ordinary maintenance feed, and the model group was fed high-fat feed, which induced SHR to produce hypertension and hyperlipidemia. During the modeling period, the blood pressure and body weight of each group of rats were measured regularly. The end point of the modeling was to determine the blood pressure, blood lipids and body weight of the rats and then sacrificed. The heart and kidney tissues were collected and their fibrotic damage was detected. Results: After 23 weeks of feeding with SHR high-fat diet, the blood lipid level was disordered; the heart and kidney organs showed obvious pathological changes: myocardial cell hypertrophy was obvious, the renal tissue interlobular artery wall was remodeled significantly, and the heart and kidney tissues were severe Fibrosis. Conclusion: SHR can successfully obtain a rat model of hypertension combined with hyperlipidemia after being fed high-fat diet for 23 weeks. Its heart and kidney target organs show obvious pathological changes, which are clinically similar to human hypertension combined with hyperlipidemia. The performance is similar, and it is expected to be widely used as a drug for the treatment of hypertension with hyperlipidemia. Or to improve the pharmacodynamic evaluation model of therapeutic drugs for this type of comorbid heart and kidney system damage.