长时程抑郁小鼠模型 z-bo 2020-12-09 361

　　Objective To construct a new type of long-term depression model mice and compare the advantages and disadvantages of this type of mice with common depression mouse models. Methods The LTD mice were constructed by early mother-infant separation and continuous chronic stress after weaning, and compared them with chronic unpredictable wild stress (CUMS) and early life stress model (ELS). ) Long-term depression-like behavior changes in mice, and compare the changes of hippocampal neurons in eGFP transgenic LTD mice and control mice.

　　 Results Compared with CUMS and ELS mice, LTD mice can show a longer-term stable depressive state in behavior. Tissue sections show that the hippocampal CA1 and CA3 areas of LTD mice are degenerative.

　　 Conclusion The LTD mice were successfully constructed. This model mice can cause longer-term depression-like behaviors and show long-term psychological stress. It is a model mouse suitable for long-term simulation of depression.