z-bo 2020-12-10 393

　　Objective To determine the growth body mass, blood physiology and biochemical indexes of SPF Hartley guinea pig core group, and compare with clean grade guinea pigs.

　　 Method Select 10 females and 10 males each in the population, and record the weight of 0-8 weeks of age by weighing; blood is collected from guinea pigs, and various physiological and biochemical indicators are detected by automatic blood cell counter and automatic blood biochemical analyzer. Results Among the blood physiological indexes of SPF guinea pigs, white blood cell count (WBC), neutrophil count (NEUT), and eosinophil count (EOS) were three indexes, which were significantly different between females and males (P<0.05) ); Platelet packed volume (PCT), platelet volume (MPV), lymphocyte count (LYM), lymphocyte percentage (LYM%), neutrophil percentage (NEUT%), eosinophil percentage (EOS%), The percentage of basophils (BAS%) showed a significant difference between female and dimensional sex (P<0.01). Among the blood biochemical indexes, alkaline phosphatase (ALP) is significantly different between the two sexes (P<0.05), and there are 3 indexes of urea nitrogen (BUN), creatinine (CREA) and cholesterol (CHO), which are extremely different between the two sexes. Significant (P<0.01). Compared with clean-grade guinea pigs, the results show that in all hematological indexes, except for white blood cell count (wbc) and female guinea pig's red blood cell volume (mcv) and platelet count (plt), there is no significant difference (p>0.05). Significant difference (P<0.01).

　　 Conclusion The growth curve of SPF guinea pigs was drawn. The hematological indexes of SPF guinea pigs are different between sexes, and there are significant differences compared with clean guinea pigs.