动物造模 z-bo 2022-06-29 401

　　[Modeling mechanism] BIO 14.6 hamster DCM model has been used for more than 30 years. This is because this animal strain has a deletion or mutation in a single gene of δ2 sarcoglycan, and DCM is naturally formed in the myocardium during development. Based on BIO14.6 hamsters, we also screened and bred some strains, such as UMX7.1, CHF147, TO-2,

　　[Characteristics of the model] BIO14.6 hamsters develop myocardial degeneration and dissolution from 30 to 40 days after birth, myocardial fibrosis from 60 to 90 days, myocardial hypertrophy at 150 days, and DCM at 250 days after 1 year of birth. The congestive heart failure seen may appear later. The pathological characteristics of this animal DCM strain are similar to humans. The different stages include typical changes in DCM: small focal myocardial necrosis and inflammatory cell infiltration. Systemic changes such as myocardial fibrosis and myocardial hypertrophy, ventricular hypertrophy and related ascites, liver and spleen congestion and swelling.

　　[Model Evaluation and Application] This hamster is very stable, more than 90% of animals eventually develop congestive heart failure, and the pathological features of dilated cardiomyopathy are human characteristics. Similar to this model animal, the myocardium has many characteristics, such as degeneration, necrosis, hypertrophy and fibrosis, which makes it suitable for the study of myocardial degeneration and anti-fibrosis therapeutics and the molecular mechanism of myocardial degeneration and necrosis. I'm. However, this model animal is relatively expensive and must be imported from abroad to reduce its use.