帕金森氏症 z-bo 2020-12-15 342

　　Dr. Cui Guohong and He Qing from the Department of Neurology, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, have made new progress in the research of Alzheimer's disease and Parkinson's disease respectively. The relevant results were recently published in Molecular Neurobiology.

　　Alzheimer's disease (AD) is the third leading killer of the elderly after cardiovascular diseases and tumors. However, the cause and mechanism of its pathogenesis are still unknown in modern medicine, and related treatment drugs lack good specificity. Cui Guohong’s rat model experiment showed that NSCs transplantation can differentiate into neurons and improve the learning and memory ability of AD rats to a certain extent. However, the AD pathological microenvironment such as Aβ deposition and immunoinflammatory reaction is not conducive to the survival, differentiation and functional integration of NSCs with the host, which seriously affects the therapeutic effect of stem cell transplantation. Studies have found that biomaterials can provide a good growth microenvironment for transplanted stem cells, which is conducive to the survival and differentiation of transplanted stem cells. Cui Guohong designed and synthesized a self-polypeptide, which can promote the survival and differentiation of NSCs in vitro and in vivo, and plays an important role in improving the effect of stem cell transplantation in the treatment of AD.

　　Parkinson's disease (PD) is another common degenerative neurological disease in the elderly. Heqing used the adenovirus vector AAV1/2 to carry the A53T point mutation α-synuclein three-dimensionally, and injected it into the substantia nigra of rats to successfully prepare a rat PD model. The rats showed reduced locomotor activity and the substantia nigra dopaminergic neurons. Loss, decreased release of striatal dopamine and other transmitters, and abnormal accumulation of α-synuclein. This model provides a good model tool for studying the pathological mechanism and intervention methods of PD mediated by α-synuclein. At the same time, Heqing found that trehalose can promote the degradation of rat substantia nigra α-synuclein by enhancing autophagy in the brain, thereby alleviating the above symptoms of PD rats. Trehalose can also inhibit the dopaminergic nerves caused by inflammation. Yuan’s apoptosis.