胰岛素抗性,阿尔兹海默病 z-bo 2020-12-15 407

　　The study, published in the journal American Medical Association Neurology, found a close association between insulin resistance and decreased memory function, which increases the risk of Alzheimer's disease. Scientist Auriel Willette said that insulin resistance is more common in people with obesity, prediabetes or type 2 diabetes.

　　 Willette and Barbara Bendlin examined 150 middle-aged and elderly people at risk of Alzheimer's disease through brain scans, but there is no sign of memory loss. Scans found that if people have a higher level of insulin resistance, a small amount of blood sugar used in the brain region is most likely to affect Alzheimer's. When this happens, the brain uses very little energy to transmit information and functions, Willette said. "If you don't have enough energy, you won't be good at remembering something or doing something," he said. "This is important for Alzheimer's disease because the use of blood sugar in certain areas of the brain gradually decreases. The blood sugar usage in these areas will eventually decrease."

　　Willette's work is mainly focused on the medial temporal lobe of the brain, especially the hippocampus, which is a key area of the brain for learning new things and long-term memory. This is also because the Alzheimer's brain shows the first large-scale shrinkage or shrinkage of areas, Willette said.

　　 Cognitive decline has a direct impact

　　 This is the first study to observe insulin resistance in middle-aged and elderly people (the average age is 60 years), and the study has determined the relationship between patterns of lowering blood sugar use and Alzheimer's disease and memory loss, Willette said.

　　 The link between insulin resistance and Alzheimer's disease is very important for prevention, but the risk is also very high. Willette said. The problem of impaired blood glucose regulation may appear at any age and affect cognitive function. Researchers test insulin resistance in obese patients and recommend ways to improve nutrition and moderate exercise to improve the condition. This is a crucial first step, he said.

　　 "It is very bad to adjust our behavior based on what may happen in the future." Willette said. "This is why people need to know about insulin resistance or related issues, which is important for treatment. Alzheimer's disease is not only present in patients with type 2 diabetes. Even patients who do not have type 2 diabetes have mild symptoms. With moderate or moderate insulin resistance, these patients may have an increased risk of Alzheimer’s disease because they exhibit many of the same types of brain regions and memory relationships.”

　　 Understanding the process of cognitive decline requires further research. Willette said those at high risk who have experienced different stages of dementia and Alzheimer's will offer to observe what is happening around them when their cognitive function declines.