HIV疫苗,动物实验 z-bo 2020-12-16 352

　　Through biomineralization technology, scientists have developed an enhanced vaccine that can evade pre-existing antibodies in the body, providing a new idea for vaccine optimization and modification including HIV vaccines. The HIV vaccine developed based on this technology has now passed animal experiments.

　　 The research team of Tang Ruikang, a professor at the Qiushi Advanced Institute of Zhejiang University, Chen Ling, a researcher at the State Key Laboratory of Respiratory Diseases at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, and a researcher at the Institute of Microbial Epidemiology, Academy of Military Medical Sciences, Qin Chengfeng, jointly completed the study.

　　 For more than 30 years, the scientific community has conducted initial clinical trials of nearly 200 AIDS vaccines, but most of them ended in failure. Chen Ling believes that "the reasons for the failure may include multiple factors, but one of them may be due to the presence of neutralizing antibodies against adenopathy in most human bodies, which can'neutralize' the adenovirus carrier used as an AIDS vaccine, rendering the vaccine ineffective. ."

　　 Scientists have modified the adenovirus vector carrying AIDS antigen. Co-first author, Dr. Xiaoyu Wang from Qiushi Advanced Research Institute of Zhejiang University, said: “We tried to use biomineralization methods to put a layer of calcium phosphate film on the vaccine to improve the performance of the vaccine.” This method Known as virus bionic mineralization technology. Wang Xiaoyu said: "The'armed' vaccine is like putting the vaccine into the'Trojan horse'. It can effectively evade the neutralizing antibody against the adenovirus itself and successfully enter the cell castle." Co-first author , Dr. Sun Caijun of Guangzhou Institute of Biomedicine and Health said that once the vaccine enters the cell castle, under the acidic environment of the lysosome in the body, the vaccine will soon break out of the "Trojan horse" to express the target antigen, and Trigger a series of immune responses. Without this coat, the adenovirus vector vaccine is like running streaking in an environment densely packed with neutralizing antibodies against adenovirus. Most vaccines cannot express antigens and induce immune responses.