黏膜细胞凋亡,过敏性疾病 z-bo 2020-12-17 330

　　Withered petals, it can "turn into spring mud to protect the flowers." However, nature is not all such a virtuous circle. A new Japanese study found that after apoptosis of animal mucosal cells, it may stimulate the immune system to "overreact" and induce autoimmune diseases and allergic diseases.

　　The mucous membranes of the intestines, skin, etc. are covered by epithelial cells. While new cells are produced inside, old cells will apoptotic and peel off, and are excreted to the body along with feces, sputum or skin dirt. It has not been discovered before that these "eliminated" cells will have any effect on the body. Researchers from the University of Tsukuba in Japan and other institutions reported in the British journal Nature Immunology that phospholipids appear on the surface of mucosal epithelial cells after apoptosis. This lipid will interact with the surface of immune cells in the intestine, trachea, and skin. A receptor protein called "CD300a" binds to trigger an immune response and induce the deterioration of autoimmune diseases. Researchers have found through animal experiments that after apoptotic epithelial cells bind to this receptor protein, the number of "regulatory T cells" in mucosal tissues such as the intestine, skin, and trachea is reduced, and this immune cell has the ability to suppress inflammation. effect.

　　The research team believes that the results of this research will help provide new treatments for a series of autoimmune diseases and allergic diseases in the future.