艾滋病,HIV-1病毒 z-bo 2021-11-05 416

　　Human Acquired Immunodeficiency Virus (HIV) is a nightmare in the medical profession. Since the disease has expanded for decades, no way can be found to completely cure the patient. The only option is to take cocktail therapy or take antiretroviral drugs (antiretroviral drugs). therapy) to slow the onset of the disease and thereby extend the life of the patient. A few days ago, a research team used gene editing technology to successfully remove the deoxyribonucleic acid (DNA) of HIV-1 from human immune cells and prevent further replication and reinfection of the virus. A research team from Temple University in the United States used CRISPR/Cas9 gene editing technology to remove the HIV-1 virus on T cells that play an important role in the human immune response, making it impossible to further infect other health cell. The so-called CRISPR/Cas9 technology is that scientists use guide RNA to change the targeted part of the cell's DNA.

　　 Earlier, this team had successfully removed HIV-1 DNA from human immune cells. The most recent study has shown that the cells that have been removed will no longer be infected by HIV. Dr. Kamel Khalili, a member of the research team, said that antiretroviral drugs can help patients control HIV infection, but as long as the patient forgets or stops taking the drug, the virus will start to replicate on its own, causing the condition to deteriorate again. .

　　 Khalili believes that this discovery is very important for different stages of development. He said: "This fully demonstrates that this gene editing technology for removing HIV virus from helper T cells with CD4 receptors is effective, and that the mutations brought to the virus genome can also allow this. The virus no longer replicates. In addition, this also means that the use of this technology can protect other cells from being infected. This technology is not only safe, but also does not bring any toxic effects." Although the current successful case is only an experiment on taking out T cells from AIDS patients, and no real human experiment has been carried out yet, Khalili believes that this technology has to deal with a very important problem in the medical community. The experimental results are quite successful, and they should continue to develop in the direction of human experiments.