糖尿病,肥胖症 z-bo 2020-12-17 312

　　New options have been evading the detection of scientists, but now scientists have finally discovered that a natural hormone composed of fat cells can help people fight diabetes and obesity. By analyzing the genes of two patients with neonatal progeria-like disease (NPS, which makes patients too low in fat), the team of Atul Chopra, Baylor College of Medicine in Houston, Texas, found that these patients were lifeless because they lacked A previously unknown gene, the researchers named the gene asprosin.

　　 "We studied this extremely rare disease and found a gene that may benefit millions of people with diabetes."

　　 Experiments in mice have shown that this hormone plays an important role in determining blood sugar levels, especially between meals. "Asprosin is released by fat cells and can reach the liver, telling the liver to release glucose into the blood immediately." When the blood sugar level rises, the hormone production process is shut down.

　　 Because these two NPS patients lack this mechanism to increase the sugar content in the blood between meals, they feel tired and weak. "I often don't feel hungry," said Abigail Solomon, who helped solve the mystery. "I eat a lot, and I often eat sugary foods at first, followed by protein."

　　 Diabetes researchers are very interested in this discovery. "Asprosin causes glucose overproduction after reaching the liver, which is an important feature of type 2 diabetes, which also makes this study more interesting." said Alan Cherrington, a diabetes expert at Vanderbilt University in Tennessee, USA. "My dream is to allow patients who rely on insulin to reduce or stop using related drugs." Chopra said, "Or we can provide diabetics with antibodies that block asprosin every week to lower their blood sugar levels. This will mean that patients can Reduce or stop insulin use altogether."

　　 Chopra’s team has registered a patent for this hormone and is now testing an antibody that inhibits asprosin. "We are treating diabetic mice and now it seems to be effective," he said. The team hopes to start human clinical trials within two to three years.

　　Asprosin can also play a role in the treatment of obesity. The Chopra team found that the blood sugar levels of obese people are twice that of non-obese people. "Our next study will focus on obesity." He said, "It is very likely that after the obesity index rises, the level of Asprosin will also rise." He said.