阿尔茨海默病 z-bo 2020-12-17 369

　　Researchers published in the American Journal of Human Genetics showed that men’s blood samples showed that Y chromosome loss developed into Alzheimer’s disease, and those who were born with genes that promoted them to develop the disease at the highest risk Same as people. The results of this research will be presented at the annual meeting of the European Society of Human Genetics. Senior author Lars Forsberg, a researcher in immunology, genetics and pathology at Uppsala University in Sweden, said: "Most genetic research nowadays focuses on genetic genetic variation, which is inherited through offspring. , But what we are exploring are the zygotic mutations acquired in daily life." Jan Dumanski, the first author of the study, said: "Using new tools to analyze gene mutations that accumulate with age will help us explain the clinical manifestations of sporadic diseases such as cancer and Alzheimer's disease."

　　 The zygotic mutation found in male biological cells is precisely the loss of the Y chromosome of blood cells to a certain extent. The incidence of Y chromosome loss among men is as high as 17%, and the older and smoking men are more likely to be found with Y chromosome loss. This study expands the view that Y chromosome loss is a well-known high risk factor for cancer (10.1038/ng.2966). This study can also be used as a predictive marker for a wider range of adverse health outcomes, especially It's Alzheimer's disease. Why the loss of the Y chromosome is linked to the increasing risk factors of disease has been unclear. But the author speculates that it may be related to the decrease in immune system performance.

　　 Researchers have investigated more than 3,000 men to determine whether there is any predictable link between the loss of the Y chromosome of blood cells and Alzheimer’s disease. Participants in the experiment come from three long-term studies that can provide routine blood specimens: European Alzheimer's disease spontaneous participants, adult males in the Ulapura longitudinal study, and elderly people in Ulapura's vascular prospective study. Throughout the entire research data, those blood cells with the highest rate without the Y chromosome are consistently more likely to be diagnosed with Alheimer's disease.

　　Forsberg said: "The loss of the Y chromosome is not a 100% prediction. You will either get cancer or Alzheimer's disease." He also added: In the experiment, men with mutations and disease-free lives can all live well to 90 years old. But in the future, blood cells that have lost the Y chromosome can become a brand new marker for disease risk factors. And perhaps the evaluation can make the problem of early detection and treatment of disease unique.

　　Forsberg, Dumanski, and his colleagues are going to investigate the impact of Y chromosome loss in a larger group, and explore in more detail how it can endanger certain types of cancers and diseases. They also plan to observe the cell changes caused by the loss of the Y chromosome and how others affect different types of blood cells.