抗衰老药物 z-bo 2020-12-21 361

　　A large number of studies at home and abroad have reported that anti-aging drugs can prolong the lifespan of many model organisms, including nematodes, fruit flies, mice, rats, and primates. However, the differences in the ways these drugs delay aging are still lacking in systematic research. Therefore, this study takes the hot model biological nematodes in aging research as the object, collects the research literature on anti-aging drug life test and the survival curve that has been officially published in domestic and foreign journals since 1990, and compares different anti-aging drugs using meta-analysis. The relationship between the drug and the type of survival curve change, and the pharmacological effects of the drug are combined to explore its life extension mechanism. The cross-analysis results of the survival curve feature clustering results and the drug biological classification showed that the pharmacological action type and the gain type have a strong correlation, suggesting that the results of the two classification methods are matched. Although the overall gain of antioxidant drugs and blood sugar control drugs on the survival curve is not the highest, the gain part of the survival curve of the normal group is in a translational shape, indicating that such drugs can produce significant gains for the entire population by improving the age structure. And the characteristics of its aging curve are similar to natural aging. Anti-epileptic drugs and gastrointestinal flora-related drugs have a large overall gain, and their curve gains are trapezoidal, indicating that although these drugs (especially gastrointestinal flora-related drugs) significantly prolong the maximum life span of a small number of individuals, they are From the perspective of the whole group, the extent of life extension of most individuals is not obvious, and the few individuals who benefit may need longer external resources to maintain a long-term survival state. This model is neither popular nor economic. In summary As mentioned, the drugs for scavenging free radicals and controlling blood sugar have more positive and reasonable effects and effects on healthy elderly.