阿尔茨海默病,小鼠模型 z-bo 2021-11-05 487

　　Recently, researchers from the University of Oslo published a new research progress in the international academic journal brain. They knocked out two genes in the mouse brain and constructed a new mouse model of Alzheimer’s disease. Different mouse models of sexual Alzheimer's disease are of great significance for the study of non-hereditary Alzheimer's disease.

　　 Alzheimer's disease is mainly caused by the abnormal deposition of beta amyloid in the brain, which can cause neuronal network damage and cause some clinical symptoms, such as orientation disorder, memory loss, behavior changes and eventually death. In basic research on Alzheimer's disease, scientists generally use transgenic methods to overexpress the Alzheimer's disease genetic gene that produces amyloid beta to construct animal models of the disease. Although these animal models have brought great convenience to the research of the disease, this method can only simulate hereditary Alzheimer's disease, but hereditary Alzheimer's disease is less than 1% of all patients with the disease .

　　 In this study, the researchers constructed a mouse model of Alzheimer's disease by simultaneously disrupting the functions of two genes in the brain. These two genes play an important role in the secretion and digestion of beta amyloid. Using this model, researchers conducted behavioral testing, electrophysiological and morphological analysis, and they found that this mouse model began to show early symptoms of the disease after 1.5 years of age, the survival rate decreased, and it was prone to anxiety in the new environment. At the same time, memory declines.

　　The researchers finally pointed out that this is a brand new animal model of Alzheimer's disease, which can realize the research of the disease without artificially overexpressing the genetic genes of Alzheimer's disease.