成年生长激素缺乏动物模型 z-bo 2020-12-22 385

　　Objective: To explore several methods for establishing adult growth hormone deficiency animal models, and provide a good model for experimental research and treatment of abnormal bone metabolism caused by growth hormone deficiency.

　　Method: Review and evaluate the method of establishing an adult growth hormone deficiency animal model by consulting the literature.

　　Results: Adult growth hormone deficiency animal models can be divided into three types: spontaneous growth hormone deficiency animal models, pituitary resection animal models, and gene knockout models.

　　Conclusion: The animal model of hypophysectomy is cheap and highly maneuverable, but it has many affected factors and is not suitable for the study of the relationship between growth hormone and bone metabolism; the price of spontaneous growth hormone deficiency animal models and gene knockout animal models It is expensive, but lacks growth hormone specifically, which is helpful to study the effect of growth hormone deficiency on bone metabolism.