2型糖尿病大鼠模型 z-bo 2020-12-24 291

　　Objective: To establish and analyze the characteristics of plasma metabolomics changes in a rat model of type 2 diabetes with abnormal black gall bladder syndrome in Uyghur medicine.

　　 Method: Establish a rat model of T2DM Uyghur medicine with abnormal savage syndrome and collect plasma samples, test the proton NMR spectrum, and perform multivariate analysis on the data. Results: The plasma glucose and lactic acid content of the rats in the simple abnormal sava syndrome group decreased, while the VLDL, LDL and carnitine content increased significantly (P<0.05); the rats in the T2DM Uyghur medicine abnormal sava syndrome group with combined disease and syndrome A variety of amino acids in plasma (alanine, isoleucine, valine, leucine, tyrosine, glutamic acid, phenylalanine, methylhistidine, glycine) as well as lactic acid and pyruvate , Glycoprotein, citric acid, creatinine, β-hydroxybutyric acid, acetoacetic acid, acetic acid, creatine, carnitine, scyllo-inositol, VLDL, LDL content decreased, while glucose and taurine content increased significantly (P< 0.05). Conclusion: Protein metabolism, phenylalanine and tyrosine metabolism pathways, glycolysis pathways and lipid metabolism pathways have undergone significant changes in the T2DM Uyghur medicine abnormal sava syndrome model rats with combined disease and syndrome; plasma metabolomics To a certain extent, the changes reflect the pathological changes that occur in the rat model of T2DM Uyghur abnormal sava syndrome with combination of disease and syndrome.