不同程度寒颤模型 z-bo 2020-12-24 388

　　OBJECTIVE: To explore the body temperature threshold of chills in rats with high fever during cooling treatment, and to construct rat models with different degrees of chills. Method: Using 20% dry yeast suspension, male SD rats weighing (200±20) g and having a basal body temperature of 36.8℃～38.3℃ were used to induce fever. Forty rats with successful fever were selected and randomly divided into 4 Groups, 10 animals in each group, used 10, 20, and 40 mL ice packs to perform exploratory cooling treatment on the neck and axilla of high fever rats for 30 minutes, while the control group did not perform cooling. Observe the performance of rat chills and monitor the rectal temperature threshold for chills in rats. Results: Within 30 minutes of the cooling treatment, the rats in the control group and the 10 mL ice pack group did not experience chills; the rats in the 20 mL ice pack group developed mild chills, which showed upright hair, head and neck Tremor, with or without upper extremity tremor, the average anal temperature threshold for mild chills was 37.25℃, and the incidence of mild chills was 100%; rats in the 40 mL ice pack group developed severe chills with erect hairs, head and neck The limbs and trunk trembled violently, and the tail muscle tension increased. The average anal temperature threshold for severe chills was 37.07℃, and the incidence of severe chills was 90%.

　　 Conclusion: Intervention with ice packs to cool rats with high fever can construct an ideal model of no chills, mild chills, and severe chills.