高血压合并高脂血症大鼠模型 z-bo 2020-12-25 679

　　Objective: To feed spontaneously hypertensive rats (SHR) with high-fat diet to construct a rat model of hypertension combined with hyperlipidemia, and evaluate its heart and kidney damage. It is a therapeutic drug for hypertension combined with hyperlipidemia Evaluation provides reference for pharmacodynamic animal models and related methods.

　　Method: 3 weeks old SHR were randomly divided into a blank control group and a model group; at the same time, Wistar-Kyoto (WKY) rats with normal blood pressure at the same age were selected as the model control group. The blank control group and the model control group were fed with ordinary maintenance feed, and the model group was fed with high-fat feed to induce SHR to produce hypertension and hyperlipidemia. During the modeling period, the blood pressure and body weight of each group of rats were measured regularly, and the rats were sacrificed after the end point of the modeling was measured. Results: After 23 weeks of feeding with SHR high-fat diet, the blood lipid level was disordered; the heart and kidney organs showed obvious pathological changes: the cardiomyocytes were hypertrophy, the interlobular arterial wall of the renal tissue was significantly remodeled, and the heart and kidney tissues were severe Fibrosis.

　　Conclusion: SHR can successfully obtain a rat model of hypertension combined with hyperlipidemia after being fed high-fat diet for 23 weeks. Its heart and kidney target organs show obvious pathological changes, which are clinically similar to human hypertension combined with hyperlipidemia. The performance is similar, and it is expected to be widely used as a drug for the treatment of hypertension with hyperlipidemia. Or to improve the pharmacodynamic evaluation model of therapeutic drugs for such complications in the heart and kidney system damage.