慢性胃肠黏膜损伤树鼩模型 z-bo 2021-11-09 500

　　Objective: To explore the feasibility of establishing an animal model of chronic gastrointestinal mucosal injury in tree shrews. Method: Twelve adult male tree shrews were randomly divided into 3 groups. Experiments 1 and 2 were divided into 2 mg/(kg·d) and 1 mg/(kg·d) 1-methyl-4-phenyl-1 groups. , 2, 3, 6-tetrahydropyridine (MPTP) dose, the control group was given the same volume of normal saline, the experimental tree shrew was injected intraperitoneally continuously for 56 days, the weight change of the tree shrew was observed, the dopamine content of cerebrospinal fluid was detected, and the gastrointestinal was observed under microscope Morphological and histopathological changes.

　　Results: The body weight and dopamine content of cerebrospinal fluid in the model group were significantly decreased, and the gastric antrum, gastric body, and duodenum all had different degrees of pathological changes, but there was no significant difference between the 2 mg/kg and 1 mg/kg dose groups. No obvious change was seen.

　　Conclusion: Long-term, low-dose intraperitoneal injection of MPTP is a feasible method for modeling tree shrews with chronic gastrointestinal mucosal damage. The optimal injection dose is 2 mg/(kg·d).